The Development and the Validation of a Novel Dissolution Method of Favipiravir Film-Coated Tablets

The aim of this study was to develop and validate a dissolution test for favipiravir release in tablet dosage form using ultra-high performance liquid chromatography (UHPLC). method developed by testing the solubility media with different pH values. results demonstrated that best achieved phosphate buffer 6.8. amount released about 100% after 30 min. UHPLC presented linearity (R = 1.000) concentration range 0.044–0.44 mg/mL. recovery parameter ranged from 102.5% 104.2%. system suitability, repeatability, intermediate precision RSD% were found be 0.36%, 1.99%, 2.49%, respectively. In addition these parameters results, an F-test performed Minitab 18 Statistical Software program repeatability results. standard sample solutions stable 2 days their respective medium. This analytical also selective favipiravir. conclusion, simple feasible short run time 2.5 min validated successfully. obtained here is adequate its purpose can applied as film-coated tablets analyses.